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APH1A: Products

Anterior pharynx-defective 1 (APH1A) is a widely expressed 36 kDa 7-transmembrane protein found in the endoplasmic reticulum and Golgi. APH1A is a component of the gamma secretase proteolytic complex which cleaves multiple substrates within their transmembrane domains. This activity liberates the intracellular domains of ErbB4, Neuregulin-1, and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1a that lacks 18 amino acids at the C-terminus.

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Human APH1A Antibody

IHCMAB6908 
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Human APH1A (NP_001071096) VersaClone cDNA

RDC0383 
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Human APH1A (NP_057106) VersaClone cDNA

RDC1144 
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