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APP: Products

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

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Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0127  
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Contains 4 membranes-2 spotted in duplicate with antibodies against 34 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
ARY025 
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Contains 4 membranes - 2 spotted in duplicate with 48 different hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0111  
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Contains 4 membranes - each spotted in duplicate with 32 different protease inhibitor antibodies
ARY023 
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