ARK5/NUAK1: Products

AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.

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Human/Mouse/Rat ARK5/NUAK1 Antibody

WBMAB6978 
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HTH 01-015


Potent and selective NUAK1 inhibitor
5622 
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WZ 4003


Potent and selective NUAK1/2 inhibitor
5177 
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