ATM: Products

Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.

Showing 1-7 out of 7 ATM Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Human Phospho-ATM (S1981) Antibody


Recombinant Monoclonal Antibody.
WBMAB22902 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat Phospho-ATM (S1981) Antibody

SW, WBAF16556  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

KU 55933


Potent and selective ATM kinase inhibitor
354437  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human ATM Antibody

IHC, WBAF2290 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human ATM Antibody

ICC/IFMAB22901 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

CGK 733


Induces apoptosis in prematurely senescent cells
26391  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

KU 60019


Potent ATM kinase inhibitor
41768  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page