Abl Kinase Inhibitors: Products

c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.

Showing 1-11 out of 11 Abl Kinase Inhibitors Products

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Imatinib mesylate


Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
5906
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Bosutinib


Dual Src-Abl inhibitor; antiproliferative
43612
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1-Naphthyl PP1


Src family kinase inhibitor; also inhibits c-Abl
30635
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Adaphostin


p210bcr/abl kinase inhibitor
37161
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AP 24534


Potent multi-kinase and pan-Bcr-Abl inhibitor
42742
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GNF 2


Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
4399
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PPY A


Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
4730
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GNF 5


Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
4908
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PKI 166 hydrochloride


Potent EGFR-kinase inhibitor
4941
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PD 180970


p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT
4965
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AV 412


Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases
4397
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