Angiopoietin-2: Products

Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that regulates vascular remodeling by promoting endothelial cell survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang-2 is required for postnatal vascular remodeling, and it cooperates with Ang-1 during lymphatic vessel development. It mediates the upregulation of ICAM-1 and VCAM-1 on EC, which facilitates the adhesion of leukocytes during inflammation. Its direct interaction with Integrins promotes tumor cell invasion. Ang-2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It associates into dimers, trimers, and larger multimers and binds the receptor Tie-2, with its function as an agonist or antagonist depending on its state of multimerization.

Showing 1-5 out of 5 Angiopoietin-2 Products

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Human Angiopoietin-2 DuoSet ELISA

ELISADY62322  
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Recombinant Human Angiopoietin-2, Biotinylated Protein, CF

BioactivityBT623B/CF2  
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Recombinant Human Angiopoietin-2, Biotinylated Protein

BioactivityBT623B2  
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Human Angiopoietin‑2 Biotinylated Antibody

BAM0981 
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Human Angiopoietin‑2 Biotinylated Antibody

WBBAF6232  
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