B-Raf: Products

The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: Raf-1 (C-Raf); A-Raf; and B-Raf, strongly expressed in fetal brain and adult cerebrum. Mice with a targeted disruption of the B-raf gene die of vascular defects during mid-gestation. B-raf mutations have been found in two-thirds of malignant melanomas, with the single substitution V599E in the kinase domain the most frequent occurrence.

Showing 1-6 out of 6 B-Raf Products

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Human B-Raf Antibody

SW, WBAF3424 
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Human/Mouse/Rat B-Raf Antibody

WBMAB3424 
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SB 590885


Potent B-Raf inhibitor
26503  
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AZ 628


Potent Raf kinase inhibitor
4836 
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GDC 0879


Potent B-Raf inhibitor
4453 
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ML 786 dihydrochloride


Potent Raf kinase inhibitor; orally bioavailable
5036 
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