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B7-H1/PD-L1: Products

B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. B7-H1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. B7-H1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, B7-H1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.

Showing 1-5 out of 5 B7-H1/PD-L1 Products

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Recombinant Human B7-H1/PD-L1 Fc Chimera Protein, CF

 156-B75  
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Recombinant Mouse B7-H1/PD-L1 Fc Chimera Protein, CF

 1019-B72  
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Recombinant Human B7-H1/PD-L1 His-tag Protein, CF

 9049-B7 
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Recombinant Mouse B7-H1/PD-L1 His-tag Protein, CF

 9048-B7 
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Recombinant Cynomolgus Monkey B7-H1/PD-L1 Fc Protein, CF

 9326-B7 
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