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B7-H2: Products

Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20-25% amino acid identity. Human and mouse B7-H2 share approximately 49% amino acid identity.

B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is a 309 amino acid (aa) protein with a putative 18 aa signal peptide, a 239 aa extracellular domain, an 18 aa transmembrane region, and a 33 aa cytoplasmic domain. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells, and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent interaction appears to play roles in T cell dependent B cell activation and T Helper (Th) cell differentiation.

Showing 1-5 out of 5 B7-H2 Products

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Recombinant Mouse B7-H2 His-tag Protein, CF

 8127-B7 
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Recombinant Human B7-H2 Fc Chimera Protein, CF

 165-B73  
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Recombinant Human B7-H2 His-tag Protein, CF

 8206-B7 
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Recombinant Mouse B7-H2 Fc Chimera Protein, CF


A New rmB7-H2 is Available! It is active on Mouse Th2 cells (D10 G4.1 cells) to induce IL-4 and has a His-tag!
New Product 8127-B7
 158-B7 
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Recombinant Cynomolgus Monkey B7-H2 Protein, CF

 9327-B7 
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