BMP and Other Activin Receptor Inhibitors: Products

Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.

Showing 1-8 out of 8 BMP and Other Activin Receptor Inhibitors Products

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A 83-01


Selective inhibitor of TGF-betaRI, ALK4 and ALK7
293927  
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Dorsomorphin dihydrochloride


Potent AMPK inhibitor
309332  
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DMH-1


Selective ALK2 inhibitor
41268  
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SB 505124


Selective inhibitor of TGF-betaRI, ALK4 and ALK7
32632  
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K 02288


Type 1 BMP receptor inhibitor
4986 
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DMH2


Type I BMP receptor inhibitor
5580 
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ML 347


Potent and selective ALK1 and ALK2 inhibitor
49451  
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LDN 193189 dihydrochloride


Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
6053 
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