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BRCA1: Products

BRCA1 and BRCA2 are intracellular proteins that function in the repair of double stranded DNA breaks by homologous recombination and thus function as tumor suppressors. Individuals with heterozygous mutations in either of these genes are at increased risk of breast, ovarian, and other cancers.

The BRCA1 (BReast CAncer gene 1) tumor suppressor protein has many reported functions. In addition to mediating signal transduction in DNA damage and repair responses, BRCA1 regulates transcriptional activity and assists in the preservation of chromosomal stability. BRCA1 is one of the first proteins recruited to sites of DNA double-strand breaks, and serves as part of a scaffold for assembling other DNA damage response or repair factors.

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Human/Mouse BRCA1 C-Terminus Antibody

Clonality: Monoclonal
Host: Mouse IgG2b Clone #440621
Applications: WB, IHC
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MAB22101

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Detection of Human/Mouse BRCA1 by Western Blot.
BRCA1 in Human Breast Cancer Tissue.
BRCA1 in Human Breast.

Human BRCA1 N-Terminus Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB, IP, IHC
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AF2210

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Detection of Human BRCA1 by Western Blot.<BR>
BRCA1 in Human Breast Cancer Tissue.

Human Phospho-BRCA1 (S1423) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: ICC/IF, WB
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AF1386

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Detection of Human Phospho-BRCA1 (S1423) by Western Blot.

Human BRCA1 C-Terminus Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: IHC
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AF6955

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BRCA1 in Human Breast Cancer Tissue.
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