BTK: Products

Bruton tyrosine kinase (Btk) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. Btk is required for B cell receptor signaling and B cell development. Defects in Btk result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, Btk contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the Btk SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC? by Btk. The autophosphorylation of Tyr223 facilitates the interaction of Btk with activated Syk. Within the SH2 domain (aa 280 - 377), human Btk shares 99% aa sequence identity with mouse and rat Btk.

Showing 1-10 out of 10 BTK Products

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Human BTK Antibody

ICC/IF, WBMAB5807 
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Human Phospho-BTK (Y223) Antibody

ICC/IF, WBMAB7205 
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Human Phospho-BTK (Y551) Antibody

SW, WBMAB7659 
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BMS 509744


Potent and selective ITK inhibitor
5009 
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(-)-Terreic acid


Selective inhibitor of BTK
1405 
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PF 06465469


Potent ITK inhibitor; also inhibits BTK
4710 
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PCI 29732


Potent BTK inhibitor
5012 
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LCB 03-0110 dihydrochloride


Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
5592 
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LFM-A13


Potent, selective BTK inhibitor
13001  
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Human BTK (NP_000052) VersaClone cDNA

RDC1707 
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