CDK2: Products

CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.

Showing 1-8 out of 8 CDK2 Products

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Human/Mouse CDK2 Antibody

ICC/IF, IHC, WBAF4654 
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SU 9516


Potent cdk2 inhibitor
29071  
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NU 6140


Cyclin-dependent kinase 2 (cdk2) inhibitor
3301 
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NU 2058


Cdk1 and cdk2 inhibitor
31351  
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AZD 5438


Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor
39682  
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CGP 60474


Potent dual cdk1/cdk2 inhibitor
5471 
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SNS 032


Potent cdk2, cdk7 and cdk9 inhibitor
40751  
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Roscovitine


Potent, selective cyclin-dependent kinase inhibitor
1332 
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