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CEACAM-5/CD66e: Products

CEACAM-5, also known as CEA and CD66e, belongs to the large family of CEACAM and pregnancy specific glycoproteins. CEACAM molecules are either transmembrane or GPI-linked, and are differentially expressed between species. Orthologs of human CEACAM-5 have not been described in other species. CEACAM-5, which is expressed primarily by epithelial cells, consists of an N-terminal Ig like V-set domain followed by six Ig-like C2-set domains and a GPI anchor. CEACAM-5 is synthesized as a 180 kDa, variably glycosylated molecule of which approximately 60% is carbohydrate. CEACAM-5 functions as a calcium independent adhesion molecule through homophilic and heterophilic interactions with CEACAM-1.

CEACAM-5 is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumors. This is consistent with a role in the development and maintenance of epithelial architecture. CEACAM-5 is upregulated in a wide variety of human tumors and is a commonly used cancer marker. It promotes tumor cell migration, invasion, adhesion, and metastasis. CEACAM-5 also contributes to tumor formation by maintaining cellular proliferation in the presence of differentiation stimuli, and by blocking apoptosis following loss of ECM anchorage (anoikis).

Showing 1-11 out of 11 CEACAM-5/CD66e Products

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Human Magnetic Luminex Assay

LXSAHM8  
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Human Luminex Assay

LXSAH4  
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Recombinant Human CEACAM-5/CD66e Protein, CF

 4128-CM 
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Human CEACAM-5/CD66e Antibody

Flow, IHC, WBMAB41281 
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Human CEACAM-5/CD66e PE-conjugated Antibody

FlowFAB41281P 
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Human CEACAM-5/CD66e APC-conjugated Antibody

FlowFAB41281A 
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Human CEACAM-5/CD66e DuoSet ELISA

ELISADY4128 
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Human CEACAM-5/CD66e (P06731) VersaClone cDNA

RDC0954 
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Human CEACAM-5/CD66e (NP_004354) VersaClone cDNA

RDC1700 
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Proteome Profiler Human sReceptor Array, Non-hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0128  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY026 
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