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CRTAM: Products

CRTAM (Class I-restricted T cell-associated molecule) is a nectin family member of the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. NK activation receptor engagement, but not cytokines, also induce NK CRTAM expression. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and in brain where it is highly expressed by Purkinje cells of the cerebellum.

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.

Showing 1-19 out of 19 CRTAM Products

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DescriptionApplicationCat#CitationsImages 

Human CRTAM Antibody


Clone 210213 was used by HLDA to establish CD designation
CyTOF-ready, Flow, WBMAB169514  
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Human CRTAM Antibody

ELISA(Cap), WBAF1695 
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Human CRTAM PE-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951P1  
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Recombinant Human CRTAM Fc Chimera Protein, CF

 1695-CR1  
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Human CRTAM Biotinylated Antibody

ELISA(Det), WBBAF1695 
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Human CRTAM APC-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951A 
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Human CRTAM Antibody

WBMAB1695 
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Human CRTAM Alexa Fluor® 750-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951S 
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Recombinant Mouse CRTAM Fc Chimera Protein, CF

 3687-CR 
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Human CRTAM DuoSet ELISA

ELISADY1695 
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Human CRTAM (NP_062550) VersaClone cDNA

RDC1546 
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Human CRTAM Alexa Fluor® 488-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951G 
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Human CRTAM Alexa Fluor® 700-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951N 
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Human CRTAM Alexa Fluor® 647-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951R 
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Human CRTAM Alexa Fluor® 594-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951T 
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Human CRTAM Alexa Fluor® 350-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951U 
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Human CRTAM Alexa Fluor® 405-conjugated Antibody


Clone 210213 was used by HLDA to establish CD designation
FlowFAB16951V 
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Mouse CRTAM (AAI17717) VersaClone cDNA

RDC2187 
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Proteome Profiler Human sReceptor Array, Hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 48 different hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0111  
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