CTLA-4: Products

CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.

Showing 1-8 out of 8 CTLA-4 Products

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Human CTLA-4 Antibody

FlowMAB3251 
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Human CTLA-4 Alexa Fluor® 488-conjugated Antibody

FlowIC3251G 
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Human CTLA-4 Alexa Fluor® 700-conjugated Antibody

FlowIC3251N 
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Human CTLA-4 Alexa Fluor® 647-conjugated Antibody

FlowIC3251R 
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Human CTLA-4 Alexa Fluor® 750-conjugated Antibody

FlowIC3251S 
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Human CTLA-4 Alexa Fluor® 594-conjugated Antibody

FlowIC3251T 
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Human CTLA-4 Alexa Fluor® 350-conjugated Antibody

FlowIC3251U 
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Human CTLA-4 Alexa Fluor® 405-conjugated Antibody

FlowIC3251V 
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