C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. Expression of human C1qTNF4 occurs most abundantly in brain and adipose tissue. Like other CTRP family members, C1qTNF4 can form dimers, trimers, hexamers, and high molecular weight oligomers following secretion. Injection of recombinant C1qTNF4 into mice can reduce food intake, body weight, and ambulatory activity levels. C1qTNF4 has also been shown to promote human cancer cell survival in vitro.