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CXCL4/PF4: Products

CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.

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Human CXCL4/PF4 Quantikine ELISA Kit

ELISADPF403  
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Mouse CXCL4/PF4 Quantikine ELISA Kit

ELISAMCX4001  
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Mouse CXCL4/PF4 DuoSet ELISA

ELISADY5958  
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Human CXCL4/PF4 DuoSet ELISA

ELISADY7956  
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Quantikine Immunoassay Control Set 800 for Human CXCL4/PF4


For use with catalog number DPF40
CtrlQC141 
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