CXCR7/RDC-1: Products

CXCR7/RDC-1 is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR7/RDC-1 is 362 amino acids (aa) in length with a predicted molecular weight of 41 kDa. Mouse and rat CXCR7/RDC-1 share 93% aa sequence identity with the human protein. CXCR7/RDC-1 binds to and acts as a scavenger for CXCL11/I-TAC and CXCL12/SDF-1. CXCR7/RDC-1 can also function as a co-receptor for HIV and SIV. Unlike other chemokine receptors, CXCR7/RDC-1 does not activate G protein signaling, but instead initiates beta-Arrestin-mediated receptor-ligand internalization. Although CXCR7/RDC-1 itself does not activate G protein signaling, the receptor can heterodimerize with CXCR4 to activate G proteins in response to CXCL12/SDF-1 binding. Studies on CXCR7/RDC-1 knockout mice suggest that it is critical for cardiovascular development. While CXCR7/RDC-1 does not appear to signal in normal hematopoietic cells, it is highly expressed in leukemic cells where it activates Akt signaling that promotes cell trafficking and adhesion. CXCR7/RDC-1 also mediates neuronal migration, displays aberrant signaling in astrocytes, and is highly expressed in glioma cells.

Showing 1-19 out of 19 CXCR7/RDC-1 Products

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Human CXCR7/RDC-1 Antibody

Flow, IHCMAB422736  
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Human CXCR7/RDC-1 Antibody

Flow, IHCMAB42273  
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Human CXCR7/RDC-1 PE-conjugated Antibody

FlowFAB42271P4  
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Mouse CXCR7/RDC-1 Antibody

Flow, WBAF42272  
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Human/Mouse CXCR7/RDC-1 APC-conjugated Antibody

FlowFAB4227A2  
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Human/Mouse CXCR7/RDC-1 PE-conjugated Antibody

FlowFAB4227P1  
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Mouse CXCR7/RDC-1 Antibody

FlowMAB71671  
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Human CXCR7/RDC-1 Fluorescein-conjugated Antibody

FlowFAB42271F1  
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TC 14012


CXCR4 antagonist; ACKR3 (CXCR7) agonist
4300 
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Human CXCR7/RDC-1 APC-conjugated Antibody

FlowFAB42271A 
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Rat CXCR7/RDC-1 APC-conjugated Antibody

FlowFAB8399A 
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Mouse CXCR7/RDC-1 APC-conjugated Antibody

FlowFAB7167A 
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Human CXCR7/RDC-1 PerCP-conjugated Antibody

FlowFAB42271C 
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Rat CXCR7/RDC-1 Antibody

FlowMAB8399 
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Rat CXCR7/RDC-1 PE-conjugated Antibody

FlowFAB8399P 
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VUF 11207 fumarate


Potent ACKR3 (CXCR7) agonist
4780 
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Rat CXCR7/RDC-1 (NP_445804) VersaClone cDNA

RDC0407 
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Human CXCR7/RDC-1 (NP_064707) VersaClone cDNA

RDC0040 
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Mouse CXCR7/RDC-1 (NP_031748) VersaClone cDNA

RDC0041 
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