Cadherin-10, also known as T2-Cadherin, is an approximately 120 kDa type I transmembrane protein belonging to the Cadherin superfamily of calcium-dependent adhesion molecules. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity. Cadherin-10 interacts homotypically as well as heterotypically with Cadherin-9 and more weakly with Cadherin-6. It is expressed in the central nervous system, particularly in the limbic system, frontal cortex, somatosensory barrel cortex (in rat), olfactory structures, epithelial cells lining the choroid plexus and ventricles, retinal pigmented epithelium, and endothelial cells of the brain and retinal microvasculature. It is also expressed on epithelial luminal cells of the prostate, as well as in testes, ovary, placenta, kidney, small intestine, and on CD4+CD8+ T cells. Cadherin-10 expression is decreased postnatally in the barrel cortex and testes. It is also downregulated in glioblastoma vasculature and prostate cancer. Polymorphisms of human Cadherin-10 are associated with autism spectrum disorders.