Cadherin-13, also known as T-Cadherin and HâCadherin, is a GPI-anchored protein belonging to the Cadherin superfamily of calcium-dependent adhesion molecules. Cadherin-13 is most highly expressed in the circulatory and nervous systems, particularly on cardiac myocytes, vascular endothelial and smooth muscle cells, and neurons and astrocytes in the brain. It exerts a negative influence on neurite extension, and it is downregulated in neurons upon NGF stimulation. Homotypic Cadherin-13 interactions promote intercellular adhesion which can be inhibited by its binding to LDL. Cadherin-13 also mediates the cardioprotective effects of Adiponectin by directly binding Adiponectin (selectively the hexameric and HMW forms) and trapping it on vascular endothelial cells and cardiomyocytes. When expressed on vascular endothelial cells Cadherin-13 promotes angiogenesis, but when expressed on stromal cells it inhibits neovascularization. Its downregulation on breast carcinoma cells and upregulation on the vasculature of various tumors limits tumor cell proliferation and angiogenesis but also enhances tumor progression.