Cadherin-6, also known as KCAD or K-Cadherin, is a 110-120 kDa type I transmembrane glycoprotein belonging to the classical Cadherin superfamily of calcium-dependent adhesion molecules. Cadherin-6 interacts homotypically as well as heterotypically with Cadherin-9 and more weakly with Cadherins-7, -10, and -14. Cadherin-6 is expressed primarily in the kidney and brain, both during development and in the adult. It is enriched in renal proximal tubule epithelial cells and their precursors at sites of cell-cell contact as well as on basolateral membranes. In the nervous system, Cadherin-6 is neuronally expressed in discrete regions of the neural plate, neural crest cells that give rise to peripheral nerves and the brain. Cadherin-6 is additionally expressed in the developing retina, osteoclasts and their progenitors, ovarian epithelium, and endometrium during the follicular phase of the menstrual cycle. It is also expressed in carcinomas of the kidney, ovary, and liver.