Caspase (Pan-specific): Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Showing 1-8 out of 8 Caspase (Pan-specific) Products

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Pan Caspase Inhibitor Z-VAD-FMK

FMK00161  
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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

OPH00112  
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Z-VAD-FMK


Cell-permeable, irreversible caspase inhibitor
216318  
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ApoStat Intracellular Caspase Detection (FITC-VD-FMK)

FlowFMK0123  
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Caspase Inhibitor Sampler Pack


100 ug each of Z-VAD-FMK, Z-WEHD-FMK, Z-VDVAD-FMK, Z-DEVD-FMK, Z-YVAD-FMK, Z-VEID-FMK, Z-IETD-FMK, Z-LEHD-FMK, Z-AEVD-FMK, and Z-LEED-FMK
FMKSP011  
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Caspase Inhibitor Control Z-FA-FMK

FMKC011  
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Ac-LEHD-AFC


Fluorogenic caspase substrate
1575 
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Pan Caspase Inhibitor Z-VKD-FMK Biotinylated

FMK011 
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