Caspase Inhibitors: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Showing 1-22 out of 22 Caspase Inhibitors Products

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Pan Caspase Inhibitor Z-VAD-FMK

FMK001111  
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Caspase-8 Inhibitor Z-IETD-FMK

FMK00760  
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Caspase-3 Inhibitor Z-DEVD-FMK

FMK00449  
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Caspase-9 Inhibitor Z-LEHD-FMK

FMK00847  
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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

OPH00126  
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Caspase-1/ICE Inhibitor Z-WEHD-FMK

FMK00220  
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Caspase-4 Inhibitor Z-YVAD-FMK

FMK00519  
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Caspase-6 Inhibitor Z-VEID-FMK

FMK00614  
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Caspase-2 Inhibitor Z-VDVAD-FMK

FMK0039  
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Z-VAD-FMK


Cell-permeable, irreversible caspase inhibitor
216326
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Caspase-10 Inhibitor Z-AEVD-FMK

FMK0098  
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Caspase Inhibitor Control Z-FA-FMK

FMKC013  
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Caspase-12 Inhibitor Z-ATAD-FMK

FMK0131  
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Caspase Inhibitor Sampler Pack


100 ug each of Z-VAD-FMK, Z-WEHD-FMK, Z-VDVAD-FMK, Z-DEVD-FMK, Z-YVAD-FMK, Z-VEID-FMK, Z-IETD-FMK, Z-LEHD-FMK, Z-AEVD-FMK, and Z-LEED-FMK
FMKSP012  
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Z-DEVD-FMK


Cell-permeable, irreversible caspase-3 inhibitor
21665
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AZ 10417808


Selective non-peptide caspase-3 inhibitor
21721
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INF 4E


Caspase-1 and NLRP3 inflammasome inhibitor
6172
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Z-DQMD-FMK


Caspase-3 inhibitor
2168
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INF 39


Irreversible NLRP3 inhibitor
6341
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CY 09


NLRP3 inhibitor; active in vivo
6436
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Caspase-13 Inhibitor Z-LEED-FMK

FMK010 
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Pan Caspase Inhibitor Z-VKD-FMK Biotinylated

FMK011 
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