Caspase Inhibitors: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Showing 1-19 out of 19 Caspase Inhibitors Products

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Pan Caspase Inhibitor Z-VAD-FMK

FMK00192  
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Caspase-8 Inhibitor Z-IETD-FMK

FMK00749  
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Caspase-3 Inhibitor Z-DEVD-FMK

FMK00441  
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Caspase-9 Inhibitor Z-LEHD-FMK

FMK00842  
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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

OPH00123  
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Caspase-1/ICE Inhibitor Z-WEHD-FMK

FMK00213  
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Caspase-4 Inhibitor Z-YVAD-FMK

FMK00514  
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Caspase-6 Inhibitor Z-VEID-FMK

FMK00611  
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Caspase-2 Inhibitor Z-VDVAD-FMK

FMK0039  
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Z-VAD-FMK


Cell-permeable, irreversible caspase inhibitor
216318  
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Caspase-10 Inhibitor Z-AEVD-FMK

FMK0096  
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Caspase Inhibitor Control Z-FA-FMK

FMKC013  
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Caspase-12 Inhibitor Z-ATAD-FMK

FMK0131  
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Caspase Inhibitor Sampler Pack


100 ug each of Z-VAD-FMK, Z-WEHD-FMK, Z-VDVAD-FMK, Z-DEVD-FMK, Z-YVAD-FMK, Z-VEID-FMK, Z-IETD-FMK, Z-LEHD-FMK, Z-AEVD-FMK, and Z-LEED-FMK
FMKSP011  
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Z-DEVD-FMK


Cell-permeable, irreversible caspase-3 inhibitor
21664  
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Z-DQMD-FMK


Caspase-3 inhibitor
2168 
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AZ 10417808


Selective non-peptide caspase-3 inhibitor
21721  
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Caspase-13 Inhibitor Z-LEED-FMK

FMK010 
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Pan Caspase Inhibitor Z-VKD-FMK Biotinylated

FMK011 
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