Caspase Inhibitors: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Showing 1-20 out of 20 Caspase Inhibitors Products

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Pan Caspase Inhibitor Z-VAD-FMK

FMK00161  
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Caspase-8 Inhibitor Z-IETD-FMK

FMK00732  
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Caspase-3 Inhibitor Z-DEVD-FMK

FMK00431  
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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

OPH00112  
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Caspase-9 Inhibitor Z-LEHD-FMK

FMK00827  
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Caspase-1/ICE Inhibitor Z-WEHD-FMK

FMK0029  
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Caspase-4 Inhibitor Z-YVAD-FMK

FMK00510  
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Caspase-2 Inhibitor Z-VDVAD-FMK

FMK0037  
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Caspase-6 Inhibitor Z-VEID-FMK

FMK0068  
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Z-VAD-FMK


Cell-permeable, irreversible caspase inhibitor
216318  
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Caspase-10 Inhibitor Z-AEVD-FMK

FMK0096  
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Caspase Inhibitor Sampler Pack


100 ug each of Z-VAD-FMK, Z-WEHD-FMK, Z-VDVAD-FMK, Z-DEVD-FMK, Z-YVAD-FMK, Z-VEID-FMK, Z-IETD-FMK, Z-LEHD-FMK, Z-AEVD-FMK, and Z-LEED-FMK
FMKSP011  
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Caspase-12 Inhibitor Z-ATAD-FMK

FMK0131  
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Caspase Inhibitor Control Z-FA-FMK

FMKC011  
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Z-DQMD-FMK


Caspase-3 inhibitor
2168 
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AZ 10417808


Selective non-peptide caspase-3 inhibitor
21721  
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Z-DEVD-FMK


Cell-permeable, irreversible caspase-3 inhibitor
21663  
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Z-VDVAD-FMK


Irreversible caspase-2 inhibitor
2165 
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Pan Caspase Inhibitor Z-VKD-FMK Biotinylated

FMK011 
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Caspase-13 Inhibitor Z-LEED-FMK

FMK010 
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