Caspase-9: Products

Caspase-9, also known as APAF-3, Mch6 and ICE-LAP6, is a 35-37 kDa member of the peptidase C14A family of enzymes. Caspase-9 is an initiator caspase that is part of the intrinsic apoptosis pathway. It is widely expressed and is particularly important during development. Following mitochondrial disruption, Cytochrome c is released from mitochrondria and interacts with APAF-1, resulting in Pro-Caspase-9 dimerization. The act of dimerization activates Pro-Caspase-9, leading to its autocleavage into p35 and p12 subunits or to its activation of Caspase-3. Activated Caspase-3 can also act on Pro-Caspase-9, generating a 37 kDa subunit and a 10 kDa subunit.

 

Showing 1-6 out of 6 Caspase-9 Products

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Caspase-9 Inhibitor Z-LEHD-FMK

FMK00845  
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Caspase-9 Colorimetric Assay Kit

K119-10030  
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Caspase-9 Fluorometric Assay Kit

K118-10022  
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Human Caspase-9 Antibody

IHC, SW, WBMAB83013  
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Human Caspase-9 Antibody

ICC/IF, WBAF83012  
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Apoptosis Activator 2


Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
20982
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