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Cathepsin D: Products

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

Showing 1-14 out of 14 Cathepsin D Products

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Mouse Cathepsin D Antibody

IHC, IP, WBAF10299  
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Recombinant Human Cathepsin D Protein, CF

 1014-AS7  
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Human Cathepsin D Antibody

IHC, IP, SW, WBAF10144  
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Human Cathepsin D Antibody

IHC, SW, WBMAB10141  
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Mouse Cathepsin D Antibody

WBMAB10294  
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Human Cathepsin D Biotinylated Antibody

IHC, WBBAF1014 
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Recombinant Mouse Cathepsin D Protein, CF

 1029-AS2  
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Mouse Cathepsin D Biotinylated Antibody

IHC, WBBAF1029 
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Human Cathepsin D Antibody

ICC/IFMAB10141 
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Proteome Profiler Human Protease Array Kit


Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies
ARY021B7  
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Proteome Profiler Human sReceptor Array, Non-hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY01210  
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Proteome Profiler Human Adipokine Array Kit


Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
ARY0241  
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Proteome Profiler Human Protease/Protease Inhibitor Array


Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
ARY0252  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY0261  
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