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Complement Component C5/C5a: Products

Human complement component C5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 74 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 alpha-chain. Human C5a has four alpha-helices plus three intrachain disulfide bonds that create a triple loop structure. In serum, proteolytic processing removes the C-terminal arginine, creating a low activity C5a desArg74 molecule. Human C5a is 60% and 54% aa identical to mouse and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (C5aR/CD88) and a non-signaling GPCR termed C5L2. Activation of CD88 results in neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells.

Showing 1-6 out of 6 Complement Component C5/C5a Products

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Human Complement Component C5/C5a Antibody

B/N, ELISA(Cap), WBMAB20372  
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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B5  
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Human Complement Component C5/C5a Antibody

B/N, WBAF20371  
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Human Complement Component C5/C5a Biotinylated Antibody

BAM20371 
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Human Complement Component C5/C5a Biotinylated Antibody

WBBAF2037 
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Proteome Profiler Mouse Chemokine Array Kit


Contains 4 membranes - each spotted in duplicate with 25 different chemokine antibodies
ARY0203  
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