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Compounds for Embryonic Stem Cell Research: Products

For many stem cell experiments, especially those with therapeutic applications, it is important to culture embryonic stem (ES) cells under defined conditions in order to reduce experimental variability. The addition of small molecules to ES cell culture media can aid in the optimization of ES cell survival, proliferation, and maintenance of pluripotency. Under certain conditions, the use of bioactive small molecules may serve as a substitute for undefined culture media. The undifferentiated and pluripotent state of ES cells can be enhanced by activation of the Wnt signaling pathway and by the addition of indole derivatives, such as ID 8. In addition, Tocris biochemicals and compounds can be used to induce the differentiation of ES cells into specialized cell types. For example, alkyl hydrazone derivatives, such as IDE-1, can activate TGF-beta signaling and induce the differentiation of ES cells into definitive endoderm.

Showing 1-29 out of 29 Compounds for Embryonic Stem Cell Research Products

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Y-27632 dihydrochloride


Selective p160ROCK inhibitor
1254148
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IWP 2


PORCN inhibitor; inhibits Wnt processing and secretion
353318
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XAV 939


Potent tankyrase inhibitor
374829
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PD 98059


MEK inhibitor
121383
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endo-IWR 1


Wnt/β-catenin signaling inhibitor; axin stabilizer
35327
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LY 294002 hydrochloride


Prototypical PI 3-kinase inhibitor; also inhibits other kinases
1130100
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Cyclopamine


Inhibitor of Hedgehog (Hh) signaling
16236
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IWP 4


Potent inhibitor of Wnt/β-catenin signaling
5214
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SB 216763


Potent, selective GSK-3 inhibitor
161672
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BIO


Potent, selective GSK-3 inhibitor
319414
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Tranylcypromine hydrochloride


Irreversible inhibitor of LSD1; also inhibits MAO
38525
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HLM 006474


E2F transcription factor inhibitor
52831
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Sodium butyrate


Histone deacetylase inhibitor
3850
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IDE 1


Induces definitive endoderm formation in mouse and human ESCs
40152
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KY 02111


Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
4731
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Theanine


Glutamate receptor ligand
3847
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Sinomenine hydrochloride


Anti-inflammatory; causes mast cell degranulation and histamine release
3848
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IDE 2


Induces definitive endoderm formation in mouse and human ESCs
4016
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A 939572


Potent SCD-1 inhibitor
4845
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ID 8


Sustains self-renewal and pluripotency of ESCs
3853
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QS 11


ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
33241
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SR 3677 dihydrochloride


Potent, selective Rho-kinase (ROCK) inhibitor
36672
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Stauprimide


Inhibits NME2 nuclear translocation; primes ESCs for differentiation
3741
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Gatifloxacin


Antibiotic; inhibits bacterial type II topoisomerase
3849
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Cardiogenol C hydrochloride


Induces cardiomyocyte differentiation in ESCs
3851
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Pluripotin


Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
4433
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Cardionogen 1


Inhibitor of Wnt/β-catenin signaling
4475
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PluriSln 1


SCD-1 inhibitor
4847
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CKI 7 dihydrochloride


CK1 inhibitor
5329
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