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Compounds for Induced Pluripotent Stem Cells: Products

Induced pluripotent stem (iPS) cells were first generated from fibroblasts by exogenously expressing four transcription factors: KLF4, c-Myc, Oct-4, and SOX2. However, somatic cell reprogramming can be inefficient, and the use of viral vectors can complicate their therapeutic potential. Thus, bioactive small molecules are important tools for optimizing iPS cell generation and research. Compounds such as Thiazovivin can be added to culture media to enhance the efficiency of iPS cell generation. Chromatin modifying small molecules, such as those that target histone deacetylases (HDACs) or methyltransferases, can also aid in somatic cell reprogramming by opening chromatin and promoting the transcription of pluripotency genes. In fact, following epigenetic changes induced by Valproic Acid, a HDAC inhibitor, iPS cells can be generated from somatic cells with the introduction of only Oct-4 and SOX2. Recent reports indicate that small molecules can also replace the function of particular transcription factors. For example, Kenpaullone, a Cyclin Dependent Kinase and GSK-3 beta inhibitor, can replace KLF4. Tocris provides a complete range of small molecules to optimize somatic cell reprogramming and reduce the need for viral-mediated transduction of transcription factors.

Showing 1-42 out of 42 Compounds for Induced Pluripotent Stem Cells Products

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SB 431542


Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
1614190
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CHIR 99021


Highly selective GSK-3 inhibitor
442351
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A 83-01


Selective inhibitor of TGF-βRI, ALK4 and ALK7
293934
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IWP 2


PORCN inhibitor; inhibits Wnt processing and secretion
353318
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PD 0325901


Potent inhibitor of MEK1/2
419216
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XAV 939


Potent tankyrase inhibitor
374829
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Valproic acid, sodium salt


Histone deacetylase inhibitor
28153
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L-Ascorbic acid


Enhances the generation of iPSCs; increases reprogramming efficiency
40554
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endo-IWR 1


Wnt/β-catenin signaling inhibitor; axin stabilizer
35327
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LY 294002 hydrochloride


Prototypical PI 3-kinase inhibitor; also inhibits other kinases
1130100
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Cyclopamine


Inhibitor of Hedgehog (Hh) signaling
16236
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Thiazovivin


Improves the efficiency of fibroblast reprogramming and induction of iPSCs
38452
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Trichostatin A


Potent histone deacetylase inhibitor
14065
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(±)-Bay K 8644


Ca2+ channel activator (L-type)
154414
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IWP 4


Potent inhibitor of Wnt/β-catenin signaling
5214
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TTNPB


Retinoic acid analog; RAR agonist
07615
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RepSox


Potent and selective inhibitor of TGF-βRI
37424
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Tranylcypromine hydrochloride


Irreversible inhibitor of LSD1; also inhibits MAO
38525
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3-Deazaneplanocin A hydrochloride


EZH2 histone methyltransferase inhibitor
47031
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Pifithrin-μ


Inhibitor of p53-mitochondrial binding
26534
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5-Azacytidine


DNA methyltransferase inhibitor
38424
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Sodium butyrate


Histone deacetylase inhibitor
3850
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IDE 1


Induces definitive endoderm formation in mouse and human ESCs
40152
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KY 02111


Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
4731
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Pifithrin-α hydrobromide


p53 inhibitor. Also aryl hydrocarbon receptor agonist
12673
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Kenpaullone


Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3
13982
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RG 108


Non-nucleoside DNA methyltransferase inhibitor
32952
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BIX 01294


GLP and G9a inhibitor
33641
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Sinomenine hydrochloride


Anti-inflammatory; causes mast cell degranulation and histamine release
3848
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IDE 2


Induces definitive endoderm formation in mouse and human ESCs
4016
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IQ 1


Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
47132
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ID 8


Sustains self-renewal and pluripotency of ESCs
3853
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QS 11


ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
33241
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SR 3677 dihydrochloride


Potent, selective Rho-kinase (ROCK) inhibitor
36672
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Cardiogenol C hydrochloride


Induces cardiomyocyte differentiation in ESCs
3851
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Cardionogen 1


Inhibitor of Wnt/β-catenin signaling
4475
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PluriSln 1


SCD-1 inhibitor
4847
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Shz 1


Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs
4923
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CKI 7 dihydrochloride


CK1 inhibitor
5329
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O4I1


Oct3/4 inducer
5639
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O4I2


Oct3/4 inducer; induces expression of pluripotent-associated genes
5664
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OAC-1


Oct4 activator; enhances iPSC reprogramming efficiency
4887
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