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Compounds for Mesenchymal Stem Cell Research: Products

Mesenchymal stem cells (MSCs) are self-renewing cells characterized by their fibroblast-like appearance and their ability to differentiate into adipocytes, chondrocytes, and osteoblasts. MSCs can be isolated from bone marrow and several other tissues. The isolated cells, often referred to as mesenchymal stromal cells, contain a heterogeneous population of cells, including a subset that demonstrate stem cell properties. MSCs can be maintained and differentiated through the use of growth factors, recombinant proteins, and small molecules. Small molecules, used alone or in combination with recombinant proteins, can facilitate mechanistic studies, enhance MSC expansion, and induce differentiation. For example, Pioglitazone, Troglitazone, or the combination of IBMX and Dexamethasone facilitate adipogenesis while Kartogenin enhances chondrogenesis. When used for mechanistic studies, small molecules can be used to rapidly activate or inhibit signaling pathways of interest. Tocris Bioscience offers a broad selection of highly pure small molecules that can be used to enhance MSC growth and differentiation as well as to facilitate mechanistic studies of MSC differentiation.

Showing 1-19 out of 19 Compounds for Mesenchymal Stem Cell Research Products

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Forskolin


Adenylyl cyclase activator
109952  
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Phorbol 12-myristate 13-acetate


Protein kinase C activator
120118  
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Retinoic acid


Endogenous retinoic acid receptor agonist
06953  
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Dexamethasone


Anti-inflammatory glucocorticoid
11263  
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H 89 dihydrochloride


Protein kinase A inhibitor
291022  
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SB 216763


Potent, selective GSK-3 inhibitor
161650  
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L-Ascorbic acid


Enhances the generation of iPSCs; increases reprogramming efficiency
40553  
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Sodium butyrate


Histone deacetylase inhibitor
3850 
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Pioglitazone hydrochloride


Selective PPARγ agonist; antidiabetic agent
41243  
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Zebularine


DNA methyltransferase and cytidine deaminase inhibitor
22933  
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5-Azacytidine


DNA methyltransferase inhibitor
38423  
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Indomethacin


Cyclooxygenase inhibitor (COX-1 > COX-2)
17085  
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Troglitazone


Selective PPARγ agonist; antidiabetic agent
3114 
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EC 23


Synthetic retinoid; induces differentiation of stem cells
4011 
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Strontium chloride


Calcium sensing receptor (CaSR) agonist
4749 
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TCS 2210


Inducer of neuronal differentiation in MSCs
38771  
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Kartogenin


Potently induces chondrogenesis in MSCs
4513 
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CW 008


PKA signaling activator; promotes osteogenesis from hMSCs
5495 
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2-Phospho-L-ascorbic acid trisodium salt


Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
5778 
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