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Compounds for Neural Stem Cell Research: Products

Neural stem cells (NSCs) are a population of adult cells with self-renewal and differentiation capacities. A major focus for NSC researchers is investigating the use of NSCs to combat age-related neurological disorders. Studies have shown that cell death associated with neurodegenerative diseases like Parkinsons disease may be ameliorated by promoting the proliferation and differentiation of endogenous NSCs. As for other stem cell types, the addition of small molecules, available from Tocris, to culture media can enhance NSC proliferation or induce differentiation. For example, the compound SB 203580 selectively inhibits p38 MAPK activity and stimulates neural stem cell proliferation. In addition, 1-Oleoyl lysophosphatidic acid (LPA) sodium salt, an agonist of LPA receptors, inhibits human embryonic stem cell-derived NSC differentiation. The use of small molecules can also enhance stem cell differentiation into cells of neuronal and glial lineages. For example, mesenchymal stem cells differentiate into cells of the neural lineage and express increased levels of the neuronal markers beta-III Tubulin and Enolase-2 when treated with the synthetic compound, C18H17N3O3.

Showing 1-34 out of 34 Compounds for Neural Stem Cell Research Products

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SB 431542


Potent, selective inhibitor of TGF-betaRI, ALK4 and ALK7
1614135  
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Y-27632 dihydrochloride


Selective p160ROCK inhibitor
1254107  
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CHIR 99021


Highly selective GSK-3 inhibitor
442331  
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A 83-01


Selective inhibitor of TGF-betaRI, ALK4 and ALK7
293927  
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Forskolin


Adenylyl cyclase activator
109952  
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DAPT


gamma-secretase inhibitor
263424  
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Dorsomorphin dihydrochloride


Potent AMPK inhibitor
309332  
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Metformin hydrochloride


Activator of LKB1/AMPK; antidiabetic agent
28645  
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Retinoic acid


Endogenous retinoic acid receptor agonist
06953  
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Valproic acid, sodium salt


Histone deacetylase inhibitor
28152  
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DMH-1


Selective ALK2 inhibitor
41268  
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1-Oleoyl lysophosphatidic acid sodium salt


Endogenous agonist of LPA1 and LPA2
38541  
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SB 203580


Selective inhibitor of p38 MAPK
120261  
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Fluoxetine hydrochloride


5-HT re-uptake inhibitor
09273  
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SU 5402


Potent FGFR and VEGFR inhibitor
330011  
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ISX 9


Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
4439 
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BIO


Potent, selective GSK-3 inhibitor
319410  
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Cyclopamine


Inhibitor of Hedgehog (Hh) signaling
16235  
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17-AAG


Selective Hsp90 inhibitor
15151  
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PD 173074


FGFR1 and -3 inhibitor
304415  
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Pifithrin-α hydrobromide


p53 inhibitor. Also aryl hydrocarbon receptor agonist
12672  
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EC 23


Synthetic retinoid; induces differentiation of stem cells
4011 
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Gliotoxin


Inhibitor of 20S proteasome; immunosuppressant
2637 
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Ciliobrevin A


Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
45291  
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Amiodarone hydrochloride


Broad spectrum ion channel blocker; antiarrhythmic
40951  
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P7C3


NAMPT activator; also proneurogenic and neuroprotective
4076 
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INDY


DYRK1A/B inhibitor
49972  
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20(S)-Hydroxycholesterol


Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation
4474 
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TCS 2210


Inducer of neuronal differentiation in MSCs
38771  
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TWS 119


GSK-3beta inhibitor; induces neuronal differentiation in ESCs
3835 
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Neurodazine


Induces neurogenesis in mature skeletal muscle cells
3656 
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Neuropathiazol


Selective inducer of neuronal differentiation in hippocampal neural progenitors
5186 
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KHS 101 hydrochloride


Selective inducer of neuronal differentiation in hippocampal neural progenitors
4888 
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O-Phospho-L-serine


Group III mGlu agonist
02381  
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