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Compounds for Stem Cell Differentiation: Products

Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

Showing 1-50 out of 60 Compounds for Stem Cell Differentiation Products

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Forskolin


Adenylyl cyclase activator
109952  
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DAPT


gamma-secretase inhibitor
263424  
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DMSO, sterile filtered


Solvent
317610  
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Dorsomorphin dihydrochloride


Potent AMPK inhibitor
309332  
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Metformin hydrochloride


Activator of LKB1/AMPK; antidiabetic agent
28645  
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IBMX


PDE inhibitor (non-selective)
28457  
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SP 600125


Selective JNK inhibitor
149669  
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AICAR


AMPK activator
284011  
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Dexamethasone


Anti-inflammatory glucocorticoid
11263  
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Retinoic acid


Endogenous retinoic acid receptor agonist
06953  
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DMH-1


Selective ALK2 inhibitor
41268  
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1-Oleoyl lysophosphatidic acid sodium salt


Endogenous agonist of LPA1 and LPA2
38541  
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AMD 3100 octahydrochloride


Highly selective CXCR4 antagonist
32999  
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A 769662


Potent AMPK activator
333615  
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Purmorphamine


Smo receptor agonist
45511  
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Fluoxetine hydrochloride


5-HT re-uptake inhibitor
09273  
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ISX 9


Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
4439 
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Sodium butyrate


Histone deacetylase inhibitor
3850 
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Zebularine


DNA methyltransferase and cytidine deaminase inhibitor
22933  
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PD 173074


FGFR1 and -3 inhibitor
304415  
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SIS3


Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling
52912  
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5-Azacytidine


DNA methyltransferase inhibitor
38423  
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IWP 4


Potent inhibitor of Wnt/beta-catenin signaling
5214 
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Thioridazine hydrochloride


Dopamine receptor antagonist; antipsychotic
30701  
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IDE 1


Induces definitive endoderm formation in mouse and human ESCs
40152  
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A 939572


Potent SCD-1 inhibitor
4845 
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ITD 1


Selective inhibitor of TGF-beta signaling; induces cardiomyocyte differentiation in ESCs
5068 
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KY 02111


Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
4731 
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EC 23


Synthetic retinoid; induces differentiation of stem cells
4011 
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P7C3


NAMPT activator; also proneurogenic and neuroprotective
4076 
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PluriSln 1


SCD-1 inhibitor
4847 
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Kartogenin


Potently induces chondrogenesis in MSCs
4513 
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CKI 7 dihydrochloride


CK1 inhibitor
5329 
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IDE 2


Induces definitive endoderm formation in mouse and human ESCs
4016 
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FH 1


Enhances iPSC-derived hepatocyte differentiation and maturation
5254 
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CW 008


PKA signaling activator; promotes osteogenesis from hMSCs
5495 
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SW 033291


High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
5759 
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TWS 119


GSK-3beta inhibitor; induces neuronal differentiation in ESCs
3835 
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GSA 10


Smo receptor agonist
4918 
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Liothyronine sodium


Thyroid hormone (T3) analog; also promotes adipogenic differentiation of MSCs
5552 
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TA 01


Induces cardiomyocyte differentiation from hESCs
5383 
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Cardiogenol C hydrochloride


Induces cardiomyocyte differentiation in ESCs
3851 
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2-Phospho-L-ascorbic acid trisodium salt


Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
5778 
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CCG 1423


Induces intermediate mesoderm differentiation from ESCs; Rho/SRF pathway inhibitor
5233 
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Cardionogen 1


Inhibitor of Wnt/beta-catenin signaling
4475 
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TA 02


Induces cardiomyocyte differentiation from hESCs
5384 
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Shz 1


Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs
4923 
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DG 172 dihydrochloride


Potent PPARbeta/delta inverse agonist; promotes BMC differentiation
5566 
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TCS 2210


Inducer of neuronal differentiation in MSCs
38771  
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KHS 101 hydrochloride


Selective inducer of neuronal differentiation in hippocampal neural progenitors
4888 
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