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Compounds for Stem Cell Differentiation: Products

Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

Showing 1-50 out of 62 Compounds for Stem Cell Differentiation Products

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Forskolin


Adenylyl cyclase activator
109953  
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DMSO, sterile filtered


Solvent
317610  
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DAPT


γ-secretase inhibitor
263427  
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Metformin hydrochloride


Activator of LKB1/AMPK; antidiabetic agent
28646  
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IBMX


PDE inhibitor (non-selective)
28457  
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Dorsomorphin dihydrochloride


Potent AMPK inhibitor
309333  
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DMH-1


Selective ALK2 inhibitor
41268  
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Retinoic acid


Endogenous retinoic acid receptor agonist
06953  
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Dexamethasone


Anti-inflammatory glucocorticoid
11263  
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SP 600125


Selective JNK inhibitor
149671  
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AICAR


AMPK activator
284011  
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1-Oleoyl lysophosphatidic acid sodium salt


Endogenous agonist of LPA1 and LPA2
38541  
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Fluoxetine hydrochloride


5-HT reuptake inhibitor
09273  
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AMD 3100 octahydrochloride


Highly selective CXCR4 antagonist
32999  
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A 769662


Potent AMPK activator
333616  
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Purmorphamine


Smo receptor agonist
45511  
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SIS3


Selective Smad3 inhibitor; inhibits TGF-βR1 signaling
52912  
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PD 173074


FGFR1 and -3 inhibitor
304415  
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LDN 193189 dihydrochloride


Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
6053 
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Zebularine


DNA methyltransferase and cytidine deaminase inhibitor
22933  
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Thioridazine hydrochloride


Dopamine receptor antagonist; antipsychotic
30701  
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Sodium butyrate


Histone deacetylase inhibitor
3850 
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IDE 1


Induces definitive endoderm formation in mouse and human ESCs
40152  
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IWP 4


Potent inhibitor of Wnt/β-catenin signaling
5214 
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5-Azacytidine


DNA methyltransferase inhibitor
38423  
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IDE 2


Induces definitive endoderm formation in mouse and human ESCs
4016 
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ISX 9


Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
4439 
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A 939572


Potent SCD-1 inhibitor
4845 
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Strontium chloride


Calcium sensing receptor (CaSR) agonist
4749 
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Lin28 1632


RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
6068 
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WHI-P 154


JAK3 kinase inhibitor. Also inhibits EGFR
3115 
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Neurodazine


Induces neurogenesis in mature skeletal muscle cells
3656 
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Stauprimide


Inhibits NME2 nuclear translocation; primes ESCs for differentiation
3741 
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TWS 119


GSK-3β inhibitor; induces neuronal differentiation in ESCs
3835 
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Cardiogenol C hydrochloride


Induces cardiomyocyte differentiation in ESCs
3851 
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TCS 2210


Inducer of neuronal differentiation in MSCs
38771  
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EC 23


Synthetic retinoid; induces differentiation of stem cells
4011 
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P7C3


NAMPT activator; also proneurogenic and neuroprotective
4076 
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Cardionogen 1


Inhibitor of Wnt/β-catenin signaling
4475 
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Kartogenin


Potently induces chondrogenesis in MSCs
4513 
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KY 02111


Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
4731 
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PluriSln 1


SCD-1 inhibitor
4847 
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KHS 101 hydrochloride


Selective inducer of neuronal differentiation in hippocampal neural progenitors
4888 
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GSA 10


Smo receptor agonist
4918 
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Shz 1


Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs
4923 
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ITD 1


Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs
5068 
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Neuropathiazol


Selective inducer of neuronal differentiation in hippocampal neural progenitors
5186 
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CCG 1423


Induces intermediate mesoderm differentiation from ESCs; Rho/SRF pathway inhibitor
5233 
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FH 1


Enhances iPSC-derived hepatocyte differentiation and maturation
5254 
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CKI 7 dihydrochloride


CK1 inhibitor
5329 
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