Cysteinyl Leukotriene R1/CysLTR1: Products

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, CysLTR1 and CysLTR2. Both receptors are members of the superfamily of G protein-coupled receptors. Activation of CysLTR1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.

Showing 1-8 out of 8 Cysteinyl Leukotriene R1/CysLTR1 Products

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MK 571


Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
23383  
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Montelukast sodium


CysLT1 and GPR17 antagonist
5904 
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Cinalukast


Potent, selective CysLT1 (LTD4) antagonist; orally active
2025 
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SR 2640 hydrochloride


Potent, selective LTD4 /LTE4 receptor antagonist
1804 
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BAY-u 9773


Dual CysLT1 and CysLT2 antagonist
3138 
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ONO 1078


Selective CysLT1 antagonist
3026 
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Mouse CysTLR1 (NP_067451) VersaClone cDNA

RDC0391 
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Human CysLTR1 (NP_006630) VersaClone cDNA

RDC0291 
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