Cysteinyl Leukotriene R2/CysLTR2: Products

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, CysLTR1 and CysLTR2. Both receptors are members of the superfamily of G protein-coupled receptors. CysLTR2 seems to play a major role in endocrine and cardiovascular systems. Stimulation of CysLTR2 by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium.

Showing 1-7 out of 7 Cysteinyl Leukotriene R2/CysLTR2 Products

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MK 571


Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
23383  
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BAY-u 9773


Dual CysLT1 and CysLT2 antagonist
3138 
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Cinalukast


Potent, selective CysLT1 (LTD4) antagonist; orally active
2025 
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ONO 1078


Selective CysLT1 antagonist
3026 
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SR 2640 hydrochloride


Potent, selective LTD4 /LTE4 receptor antagonist
1804 
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Human CysLTR2 (NP_065110) VersaClone cDNA

RDC0292 
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Mouse CysTLR2 (NP_598481) VersaClone cDNA

RDC0450 
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