DDR1: Products

DDR1, also known as CAK, CD167a, RTK6, and TrkE, is a 120-140 kDa type I transmembrane glycoprotein that belongs to the discoidin-like domain containing subfamily of receptor tyrosine kinases and serve as receptors for collagen. DDR1 is expressed on epithelial tissues, activated monocytes and neutrophils, and in several cancers. Compared to isoform DDR1b, DDR1a lacks 37 aa’s that include a Shc-interacting NPxY motif in the cytoplasmic juxtamembrane region. Two additional kinase deficient splice forms are expressed in colon cancer. The discoidin-like domain mediates binding to collagens I-V. DDR1 selectively recognizes the triple helical structure of collagen. It is expressed on the cell surface as a dimer which can include different isoforms. DDR1 oligomerization enhances collagen binding and also modulates collagen fibrillogenesis. The transmembrane segment contains a leucine zipper and GxxxG motif, but neither is exclusively required for dimerization. Collagen binding induces prolonged autophosphorylation, including the NPxY motif. Collagen binding also results in the proteolytic cleavage of a tyrosine phosphorylated 60 kDa C-terminal fragment (CTF), and a 60 kDa ECD fragment. TIMP-3 and TAPI-1 inhibit shedding of the ECD fragment but not the CTF. Overexpression of DDR1a promotes MMP-2 activation and results in an increased invasiveness of a glioblastoma cell line; DDR1b does not.

Showing 1-9 out of 9 DDR1 Products

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Human DDR1 Antibody

IHC, SW, WBAF23962  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B96  
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Recombinant Human DDR1 Fc Chimera Protein, CF

 2396-DR2  
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Human Phospho-DDR1 DuoSet IC ELISA

ELISADYC5859-2 
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Human DDR1 Biotinylated Antibody

WBBAF23961  
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DDR1-IN-1 dihydrochloride


Selective DDR1 inhibitor
50771  
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Recombinant Mouse DDR1 Fc Chimera Protein, CF

 6416-DR 
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Human DDR1 Antibody

IPMAB2396 
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Human Total DDR1 DuoSet IC ELISA

ELISADYC2396-2 
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