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DDR2: Products

DDR2, also known as TYR010 and TKT, is a widely expressed 130 kDa type I transmembrane glycoprotein belonging to the discoidin-like domain containing subfamily of receptor tyrosine kinases. Mature human DDR2 consists of a 378 amino acid (aa) extracellular domain (ECD) that includes the discoidin like domain, a 22 aa transmembrane segment, and a 434 aa cytoplasmic domain that includes the kinase domain. Within the ECD, human DDR2 shares 53% aa sequence identity with DDR1 and 97% aa sequence identity with mouse DDR2. The discoidin-like domain mediates DDR2 interactions with collagens I, III, and X. Collagens II and V are less efficacious ligands.

DDR2 selectively recognizes the triple helical structure of collagen compared to monomeric or denatured collagen. Within collagen II, the D2 period is required for DDR2 binding, and the D1 period is additionally required to trigger DDR2 auto-phosphorylation. The ECD of DDR2 exists as a noncovalent dimer in solution, and dimerization of the receptor greatly enhances collagen binding. DDR2 interaction with collagen I inhibits collagen fibrillogenesis and alters collagen fiber morphology. Ligand binding induces DDR2 auto-phosphorylation in the cytoplasmic domain, which promotes associations with Shc and Src. In addition to the above mechanism, DDR2 exhibits a distinct interaction with collagen X. A region other than the discoidin-like domain of DDR2 recognizes the non-helical NC1 domain of collagen X, and this interaction does not lead to receptor auto-phosphorylation. Activation of DDR2 by collagen induces upregulation of MMP1, 2, and 13 as well as DDR2 itself. DDR2 is implicated in collagenous matrix destruction and cell invasiveness. DDR2 is also upregulated in several pathological conditions, including hepatic fibrosis following injury, rheumatoid and osteoarthritis, and smooth muscle cell hyperplasia.

Showing 1-18 out of 18 DDR2 Products

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Human DDR2 Antibody

IHC, SW, WBAF25385  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B135  
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Human Phospho-DDR2 (Y740) Antibody


Recombinant Monoclonal Antibody.
SW, WBMAB253821  
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Human DDR2 Antibody

IHC, WBMAB25382  
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Human DDR2 Antibody

CyTOF-ready, Flow, IHCMAB253811  
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Recombinant Human DDR2 Protein, CF

 2538-DR 
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Human DDR2 Biotinylated Antibody

WBBAF2538 
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Human Phospho-DDR2 DuoSet IC ELISA

ELISADYC6170-21  
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LCB 03-0110 dihydrochloride


Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
5592 
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Recombinant Mouse DDR2 Fc Chimera Protein, CF

 7479-DR 
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Human Total DDR2 DuoSet IC ELISA

ELISADYC2538-2 
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Human DDR2 Alexa Fluor® 488-conjugated Antibody

FlowFAB25381G 
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Human DDR2 Alexa Fluor® 700-conjugated Antibody

FlowFAB25381N 
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Human DDR2 Alexa Fluor® 647-conjugated Antibody

FlowFAB25381R 
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Human DDR2 Alexa Fluor® 750-conjugated Antibody

FlowFAB25381S 
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Human DDR2 Alexa Fluor® 594-conjugated Antibody

FlowFAB25381T 
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Human DDR2 Alexa Fluor® 350-conjugated Antibody

FlowFAB25381U 
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Human DDR2 Alexa Fluor® 405-conjugated Antibody

FlowFAB25381V 
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