DNMT1: Products

DNMT1 (DNA methyltransferase 1; also MCMT and CXXC-type Zn finger protein 9) is a 190 kDa member of the C5-methyltransferase family of enzymes. DNMT1 is ubiquitous in expression, and appears during the S-phase of the cell cycle. DNMT1 catalyzes the attachment of a methyl group to the C5 position of CpG cytosines using AdoMet/adenosylmethionine as a co factor. This acts to silence select genes during X chromosome inactivation and tumorigenesis. Human DNMT1 is 1616 amino acids (aa) in length. DNMT1 contains an N-terminal regulatory, homodimerization and target recognition region (aa 1-1100), a Gly-Lys linker segment (aa 1109-1120) and a catalytic domain (aa 1121-1616). DNMT1 is acetylated, phosphorylated, and SUMOylated. There are multiple splice variants of DNMT1. There is a deletion of aa 1-336, alternative start sites at Met122 and 62 aa upstream of the standard start site, and a 17 aa substitution for Pro149. Over aa 1381-1587, human DNMT1 shares 87% aa identity with mouse DNMT1.

Showing 1-6 out of 6 DNMT1 Products

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Human DNMT1 Antibody

ICC/IF, WBAF6110 
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5-Azacytidine


DNA methyltransferase inhibitor
38423  
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Zebularine


DNA methyltransferase and cytidine deaminase inhibitor
22933  
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Decitabine


DNA methyltransferase inhibitor
26244  
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RG 108


Non-nucleoside DNA methyltransferase inhibitor
32952  
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SGI 1027


DNA methyltransferase inhibitor
5155 
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