Dkk-4: Products

Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

Showing 1-11 out of 11 Dkk-4 Products

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Recombinant Human Dkk-4 Protein

 1269-DK2  
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Mouse Dkk-4 Antibody

WBAF31051  
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Human Dkk-4 Biotinylated Antibody

ELISA(Det), WBBAF1269 
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Human Dkk-4 Antibody

ELISA(Cap), WBMAB1269 
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Recombinant Human Dkk-4 Protein, CF

 1269-DK/CF2  
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Human Dkk-4 Antibody

WBAF1269 
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Recombinant Mouse Dkk-4 Protein

 3105-DK1  
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Recombinant Mouse Dkk-4 Protein, CF

 3105-DK/CF1  
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Mouse Dkk-4 Biotinylated Antibody

WBBAF3105 
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Human Dkk-4 DuoSet ELISA

ELISADY1269 
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Proteome Profiler Human Cell Stress Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
ARY0182  
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