Dkk-4: Products

Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and Kremen-2 with high affinity. Kremen-2 can form a ternary complex with Dkk-1 or Dkk-4 plus LRP5/6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, Dkk-1/4 and Kremens function synergistically to antagonize LRP5/6-mediated Wnt activity.

 

Showing 1-11 out of 11 Dkk-4 Products

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Recombinant Human Dkk-4 Protein

Bioactivity1269-DK2  
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Recombinant Human Dkk-4 Protein, CF

Bioactivity1269-DK/CF2  
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Mouse Dkk-4 Antibody

WBAF31052  
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Recombinant Mouse Dkk-4 Protein

Bioactivity3105-DK1  
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Recombinant Mouse Dkk-4 Protein, CF

Bioactivity3105-DK/CF1  
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Human Dkk-4 Biotinylated Antibody

ELISA(Det), WBBAF1269 
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Human Dkk-4 Antibody

ELISA(Cap), WBMAB1269 
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Human Dkk-4 Antibody

WBAF1269 
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Mouse Dkk-4 Biotinylated Antibody

WBBAF3105 
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Human Dkk-4 DuoSet ELISA

ELISADY1269 
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Proteome Profiler Human Cell Stress Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
ARY0184  
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