Dopamine beta-Hydroxylase: Products

Dopamine β-hydroxylase (DβH; also dopamine β-monooxygenase) is a 73 - 77 kDa member of the copper type II ascorbate-dependent monooxygenase family. It is both soluble (73 kDa) and membrane-bound (77 kDa) (anchored by an uncleaved signal sequence), and via hydroxylation, converts dopamine into norepinepherine.

Human DβH is a copper-containing disulfide-linked homodimer that is found in neurons and adrenal medullary cells. It is 603 amino acids (aa) in length and contains a 25 aa signal sequence followed by three domains. The first is an N-terminal 120 aa DOMON domain (dopamine β-monooxygenase N-terminal) that may either bind DβH to the cell membrane, or participate in tetramerization. This is followed by two 150 aa Cu+-type II ascorbate-dependent monooxygenase domains (aa 182 - 330 and 352 - 512). DβH may be most active as a dimeric-dimer/tetramer, whose association status is dependent on local Cl- concentrations.

Showing 1-5 out of 5 Dopamine beta-Hydroxylase Products

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Human/Primate Dopamine beta -Hydroxylase N-Terminus Antibody

WBPPS0671  
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Human/Mouse/Primate Dopamine beta -Hydroxylase C-Terminus Antibody

WBPPS066 
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Human Dopamine beta -Hydroxylase Antibody

WBAF7376 
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Recombinant Human Dopamine beta-Hydroxylase Protein, CF

 7376-AO 
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Nepicastat hydrochloride


Potent and selective dopamine beta-hydroxylase (DBH) inhibitor; orally bioavailable
5037 
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