EBI2: Products

EBI2 was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. EBI2 is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor and signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha. EBI2 is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. EBI2 is an orphan receptor that plays a central role during humoral immunity and promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses.

Showing 1-4 out of 4 EBI2 Products

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NIBR 189


Potent and selective EBI2 (GPR183) receptor antagonist
5203 
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7α,25-Dihydroxycholesterol


Highly potent GPR183 (EBI2) agonist
6277 
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Human EBI2 (NP_004942) VersaClone cDNA

RDC0219 
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Mouse EBI2 (NP_898852) VersaClone cDNA

RDC0445 
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