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ENPP-2/Autotaxin: Products

ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.

Showing 1-12 out of 12 ENPP-2/Autotaxin Products

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Human Magnetic Luminex Assay

LXSAHM7  
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Human Luminex Assay

LXSAH4  
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Human ENPP-2/Autotaxin Quantikine ELISA Kit

ELISADENP202  
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Recombinant Human ENPP-2/Autotaxin Protein, CF

 5255-EN 
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Human ENPP-2/Autotaxin Antibody

IP, WBAF52551  
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Recombinant Mouse ENPP-2/Autotaxin Protein, CF

 6187-EN1  
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Human ENPP-2/Autotaxin DuoSet ELISA

ELISADY5255-051  
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S 32826


Potent autotaxin inhibitor
3404 
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HA 130


Selective autotaxin inhibitor
4196 
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PF 8380


Potent autotaxin inhibitor
4078 
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Quantikine Immunoassay Control Set 701 for Human ENPP-2


For use with catalog number DENP20
CtrlQC84 
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY026 
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