ERK1/ERK2: Products

ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.

ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.

Showing 1-17 out of 17 ERK1/ERK2 Products

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Human/Mouse/Rat Phospho-ERK1(T202/Y204)/ERK2 (T185/Y187) Antibody

CyTOF-ready, Flow, IHC, SW, WBAF101812  
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Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) DuoSet IC ELISA

ELISADYC1018B-218  
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Human/Mouse/Rat Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody

CyTOF-ready, Flow, ICC/IF, SW, WBMAB10186  
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Human/Mouse/Rat ERK1/ERK2 Antibody

IHC, WBMAB15765  
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Proteome Profiler Human Phospho-Kinase Array Kit


Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B101  
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Human/Mouse/Rat ERK1/ERK2 Antibody

SW, WBAF15764  
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Human Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody

WBMAB1825 
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Human/Mouse/Rat ERK1/ERK2 Antibody

WBMAB15761 
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Eicosapentaenoic Acid


Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation
5979 
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