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Endostatin: Products

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

Showing 1-17 out of 17 Endostatin Products

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Human Magnetic Luminex Assay

LXSAHM25  
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Human Luminex Assay

LXSAH5  
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Human Endostatin Quantikine ELISA Kit

ELISADNST018  
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Mouse Endostatin Antibody

IHC, WBAF5705  
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Human Endostatin Antibody

IHC, WBAF10983  
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Proteome Profiler Human Angiogenesis Array Kit


Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
ARY00767  
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Human Endostatin DuoSet ELISA

ELISADY10984  
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Human Endostatin Biotinylated Antibody

IHC, WBBAF10981  
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Mouse Endostatin Antibody

WBMAB5702  
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Proteome Profiler Mouse XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
ARY0286  
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Mouse Endostatin Biotinylated Antibody

WBBAF570 
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Recombinant Human Endostatin Protein, CF

 1098-ES 
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Recombinant Mouse Endostatin Protein, CF

 570-ES 
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Human Endostatin Magnetic Luminex Performance Assay

LANM1098 
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Quantikine Immunoassay Control Set 860 for Human Endostatin


For use with catalog numbers DNST0, SNST0, PDNST0
CtrlQC81 
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY0261  
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Proteome Profiler Rat XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
ARY030 
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