ErbB2/Her2: Products

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

Showing 1-13 out of 13 ErbB2/Her2 Products

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B/N, Flow, IHC, WBAF11293  
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ELISA(Cap), Flow, ICC/IF, IHC, WBMAB11291  
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FlowFAB1129P3  
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ELISA(Det), ICC/IF, IHC, WBBAF11292  
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IHCMAB11291 
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IHC, SW, WBAF17681  
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IHC, SW, WBAF4438 
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IHC, WBAF5176 
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FlowFAB1129A1  
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FlowMAB6744 
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FlowFAB6744A 
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FlowFAB6744P 
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WBMAB4360 
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