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FGF-8: Products

FGF-8 is a member of the fibroblast growth factor family that was originally discovered as a growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Alternate splicing of mouse FGF-8 mRNA generates eight secreted isoforms, designated a - h, but only FGF-8a, b, e and f exist in humans. FGF-8 contains a 22 amino acid (aa) signal sequence, an N-terminal domain that varies according to the isoform (30 aa for FGF-8b; 20 aa for the shortest, FGF-8a), a 125 aa FGF domain and a 37 aa proline-rich C-terminal sequence. The FGF domain of FGF-8 shares the most aa identity with FGF-17 (75%) and FGF-18 (67%), and the three form an FGF subfamily. Mouse FGF-8b shares 100% aa identity with human FGF-8b. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an organizing and inducing role during gastrulation, and regulates patterning of the midbrain/hindbrain, eye, ear, limbs and heart in the embryo. The isoforms may play different roles in development. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity although FGF-8a and FGF-8e are also transforming and have been found in human prostate, breast or ovarian tumors. FGF-8 shows limited expression in the normal adult, but low levels are found in the reproductive and genitourinary tract, peripheral leukocytes and bone marrow hematopoietic cells.
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Recombinant Human/Mouse FGF-8b Protein, CF

22 Citations
Source: E. coli
Accession #: NP_006110 (human), NP_00115983
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423-F8/CF

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FGF 8_423
FGF 8_423

Recombinant Human/Mouse FGF-8b Protein

22 Citations
Source: E. coli
Accession #: NP_006110 (human), NP_00115983
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423-F8

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FGF 8_423
FGF 8_423

Recombinant Human FGF-8a Protein, CF

2 Citations
Source: E. coli
Accession #: NP_149355
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4745-F8

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FGF 8_4745
FGF 8_4745

Recombinant Mouse FGF-8c Protein, CF

3 Citations
Source: E. coli
Accession #: P37237
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424-FC/CF

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Recombinant Mouse FGF-8c Protein

3 Citations
Source: E. coli
Accession #: P37237
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424-FC

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Recombinant Human FGF-8e Protein, CF

2 Citations
Source: E. coli
Accession #: NP_149354
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4746-F8

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Recombinant Human FGF-8f Protein, CF

Source: E. coli
Accession #: AAH69106
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5027-FF/CF

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Recombinant Human FGF-8f Protein

Source: E. coli
Accession #: AAH69106
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5027-FF

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