Frizzled-8: Products

This group of G protein-coupled receptors consists of 10 structurally-related, seven transmembrane proteins with a divergent N-terminal signal peptide and a variable-length C-terminal tail. The Frizzled family proteins contain a highly conserved cysteine-rich domain and a variable length linker region. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Planar Cell Polarity and Wnt/Ca2+ Pathways). Wnt/Frizzled signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning, and control of cell proliferation. Activation of a given Wnt/Frizzled signaling cascade is dependent on the Wnt ligand and the cell context. Frizzled proteins also form co-receptor complexes with LRP, ROR, and Ryk molecules.

Showing 1-7 out of 7 Frizzled-8 Products

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Recombinant Human Frizzled-8 Fc Chimera Protein, CF

 6129-FZ2  
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Recombinant Mouse Frizzled-8 Fc Chimera Protein, CF

 112-FZ3  
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Mouse Frizzled-8 Antibody

IHC, WBAF112 
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Mouse Frizzled-8 Antibody

WBMAB112 
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Mouse Frizzled-8 Biotinylated Antibody

WBBAF112 
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Mouse Frizzled-8 (NP_032084) VersaClone cDNA

RDC0293 
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Human Frizzled-8 (NP_114072) VersaClone cDNA

RDC0816 
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