GABA-A R alpha 5: Products

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

The rat α5 isoform is a 439 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 25 - 232). The α5 subunit is unusual in that it contains an N-terminal histidine which renders it very sensitive to zinc. It is also associated with extrasynaptic sites and seems to mediate tonic inhibition in hippocampal neurons.

Showing 1-3 out of 3 GABA-A R alpha 5 Products

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L-655,708


Benzodiazepine inverse agonist; selective for alpha5-containing GABAA receptors
13274  
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Mouse/Rat GABA-A R alpha 5 C-Terminus Antibody

WBPPS027 
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Human GABA-A R alpha 5 (NP_000801) VersaClone cDNA

RDC0899 
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