GDF-1: Products

Growth and Differentiation Factor 1 (GDF-1) is a 12 - 15 kDa secreted protein in the TGF-beta superfamily. It is the functional equivalent of frog, zebrafish, and chick Vg1. GDF-1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus. It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord. It cooperates with Nodal and GDF-3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF-1-Nodal heterodimer. The presence of Nodal is required for GDF-1 induced effects. GDF-1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF-CFC protein such as Cryptic or Cripto. Loss of function mutations in GDF-1 are associated with a variety of human cardiac development defects.

 

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Recombinant Human GDF-1 Protein

Bioactivity6937-GD1  
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Recombinant Human GDF-1 Protein, CF

Bioactivity6937-GD/CF1  
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Human GDF-1 Antibody

WBMAB6937 
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Mouse GDF-1 Propeptide Antibody

WBAF3069 
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Mouse GDF-1 Antibody

WBAF858 
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Mouse GDF-1 Propeptide Biotinylated Antibody

WBBAF3069 
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Mouse GDF-1 Biotinylated Antibody

WBBAF858 
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