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IGF-I R: Products

IGF-IR (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-I with high affinity, IGF-II with lower affinity, and Insulin with lowest affinity. IGF-I R/Insulin R hybrids respond primarily to IGF-I and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R. Mice lacking IGF-I R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF-I R mutations in humans can retarded pre- and postnatal growth. IGF-I and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF-IR expression on human embryonic stem cells is important for their survival and clonogenicity.

Showing 1-23 out of 23 IGF-I R Products

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DescriptionApplicationCat#CitationsImages 

Human IGF-I R Antibody

B/N, ELISA(Cap), WBMAB39111  
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Recombinant Human IGF-I R Protein, CF

 391-GR1  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B96  
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Human/Mouse IGF-I R Antibody

B/N, IHC, WBAF-305-NA5  
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Recombinant Human IGF-I R (Histidine-tagged) Protein, CF

 305-GR1  
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Human Phospho-Insulin R (Y1162/Y1163)/
IGF-I R (Y1135/Y1136) Antibody

Flow, ICC/IF, WBAF25073  
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Human IGF-I R Biotinylated Antibody

ELISA(Det), WBBAF3911  
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Human Phospho-IGF-I R DuoSet IC ELISA

ELISADYC1770-22  
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Human Total IGF-I R DuoSet IC ELISA

ELISADYC305-23  
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Human IGF-I R PE-conjugated Antibody

FlowFAB391P3  
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Human IGF-I R DuoSet ELISA

ELISADY3914  
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Recombinant Mouse IGF-I R Protein

 6630-GR 
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Recombinant Mouse IGF-I R Protein, CF

 6630-GR/CF 
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Picropodophyllotoxin


Selective IGF1R inhibitor
29561  
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Human IGF-I R PerCP-conjugated Antibody

FlowFAB391C1  
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Human IGF-I R Fluorescein-conjugated Antibody

FlowFAB391F1  
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PQ 401


IGF1R inhibitor
27685  
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BMS 536924


Dual IR/IGF1R inhibitor
47741  
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GSK 1838705


Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
5111 
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NBI 31772


High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
5192 
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NVP ADW 742


ATP-competitive inhibitor of IGF1R
5247 
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Proteome Profiler Mouse Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
ARY0147  
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Proteome Profiler Human Ubiquitin Array


Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
ARY027 
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